Peptides

Acetyl Hexapeptide-8 is a synthetic peptide with neurotransmitter-inhibiting properties which serves an anti-aging purpose in skincare products. Comprising six amino acids linked together, this peptide is recognized for its efficacy in reducing the visibility of wrinkles and fine lines by inhibiting specific muscle movements. It is believed to work similarly to Botox but without the need for injections. Acetyl Hexapeptide-8 enhances the appearance of expression lines, reduces muscle stiffness, and diminishes expression wrinkles. It is believed to interfere with the signals responsible for muscle contractions, leading to a temporary smoothing effect on the skin.

Acetyl Hexapeptide-38 is a synthetic peptide composed by six amino acids mainly focused on the increasing of breast volume. Stimulates adipogenesis and lipogenesis, thereby increasing the thickness of adipose tissue and lipid accumulation, resulting in a fuller and firmer skin. This peptide serves as an outstanding active ingredient for shaping the body by enhancing local volume where needed. It acts as a volume booster, capable of increasing local volume and reversing age-related volume losses. This makes it an essential component in replenishing treatments to apply on the neck, décolletage, face, breasts, and buttocks.

Acetyl Octapeptide-3 is a synthetic peptide composed by eight amino acids used for skin care products for its anti-aging purpose. It works by disrupting the release of neurotransmitters responsible for signaling muscle contractions. By reducing muscle activity, it aims to minimize the appearance of wrinkles and fine lines, particularly those resulting by daily facial expressions. Functioning in a manner that mimics the mechanism of Botox, its incorporation into skincare products is designed to provide users with a non-invasive option to address the visible signs of aging, contributing to a smoother and more youthful-looking complexion face.

Acetyl Tetrapeptide-5 is a synthetic peptide specifically formulated to address concerns commonly associated with the sensitive and delicate eye area. Possesses potential properties that can effectively diminish puffiness and under-eye bags. Furthermore, contributes to enhance skin elasticity and firmness in the eye contour. The mechanism of action of Acetyl Tetrapeptide-5 is intricately linked to its influence on factors associated with fluid balance and inflammation. By modulating these crucial elements, the peptide aims to create a harmonious environment that fosters a more refreshed and rejuvenated appearance in the eye area. This multifaceted approach underscores its commitment to not only addressing visible concerns but also contributing to the long-term resilience and vitality of the delicate skin around the eyes.

Biotinoyl Tripeptide-1 is a cosmetic ingredient which stimulates the metabolism of hair follicle cells specifically targeting hair growth and volume. Through its synergistic combination with biotin, the peptide’s functionality is further enhanced. Biotin is an essential vitamin which plays a crucial role in maintaining the health of hair, improving so its strength and condition. As a result, the hair feels softer and smoother giving it a stronger and healthier appearance.

Copper tripeptide-1 is a small protein composed of the three amino acids glycine, histidine, and lysine combined with the physiologically beneficial mineral copper. Functioning as an anti-aging and as a hair growth stimulating ingredient, increases keratinocyte proliferation and facilitates the synthesis of collagen, a fundamental protein in skin’s structure. This dual action leads to an enhanced skin elasticity and a reduction of wrinkles, fortifying the protection for the skin's barrier function.

Tripeptide-3, also named dipeptide diaminobutyroyl benzylamide diacetate, mimics the effect of waglerin-1, a peptide that is found in the venom of the viper Tropidolaemus Wagleri. Waglerin-1 has been shown to block the nicotinic acetylcholine receptors at the neuromuscular junction, thus inhibiting muscular movement. The function of the Wagerlin-1-mimicking peptide is important for the treatment of lines since facial areas associated with repeated muscle movement are especially susceptible to wrinkle formation.

L-Carnosine, also known simply as Carnosine, is a dipeptide molecule composed of two amino acids: beta-alanine and histidine, naturally present in various tissues of the body. It is an historically known peptide for its powerful different antioxidant properties being the focus of numerous studies. Research indicates that it plays a protective role against glycation, thereby preventing cellular damage and contributing to the improvement of skin texture and appearance reducing roughness and expression lines. As an intriguing and potent ingredient, L-Carnosine holds promise for incorporation into any anti aging product.

The cellular defense against reactive oxygen species relies on antioxidant enzymes and small molecules. L-ergothioneine, a powerful antioxidant obtained from the diet, accumulates in cells exposed to high oxidative stress. Its protective role depends on the L-ergothioneine-specific receptor/transporter OCTN1, as it cannot permeate the plasma membrane.

Myristoyl Pentapeptide-17 is a potent ingredient renowned for its role in promoting eyelash growth. Its mechanism of action involves stimulating the expression of the keratin gene, a pivotal factor in the structural integrity of hair. This stimulation results in the increased proliferation of keratinocytes within the hair bulb, a crucial region for the development and nourishment of hair follicles. Myristoyl Pentapeptide-17 manifests its efficacy by imparting a dual benefit of both thickening and lengthening eyelashes. This transformative action contributes to an overall stronger and more voluminous appearance of the eyelashes, making it a highly sought-after ingredient for inclusion in eyelash serums and other formulations targeted at enhancing lash beauty.

Palmitoyl hexapeptide-12 offers promising anti-aging benefits for the skin as it has been developed to stimulate elastin synthesis by promoting the stimulation of collagen production. It stimulates collagen and elastin fibroblasts, as well as develops glycosaminoglycans and fibronectin. The intracellular mechanism refers to the way in which it can reduce the production of proinflammatory mediators (IL1, IL-6, and IL-8) and ultimately slow down the skin matrix’s degradation leading to improved skin aging signals. Consequently, Palmitoyl Hexapeptide-12 is highly valued as a sought-after ingredient in antiaging skincare formulations.

Palmitoyl Pentapeptide-4 is a powerful booster of collagen, crucial for keeping the skin firm and elastic. It works by restructuring the skin and is especially effective in increasing collagen types I, III, and IV, as well as fibronectin and glycosaminoglycans. Palmitoyl Pentapeptide-4 contains a key component, proline, which, when converted to hydroxyproline, directly influences collagen synthesis. This ingredient is known for reducing wrinkles and fine lines, making it a popular choice for addressing signs of aging. By supporting collagen production, Palmitoyl Pentapeptide-4 helps improve skin firmness, counteracting the natural loss of collagen that comes with aging.

Palmitoyl Tetrapeptide-7, also known as Palmitoyl Tetrapeptide-3, is a short chain of four amino acids: glycine, glutamine, proline, and arginine. This peptide is often used in anti-aging skincare products because it not only stimulates collagen production, but also reduces IL-6 secretion and inflammation calming the skin of external effects such sun exposure and pollution. By promoting collagen production, Palmitoyl Tetrapeptide-7 helps minimize the appearance of fine lines and wrinkles, leading to a smoother and more youthful complexion.

Palmitoyl tripeptide-1 is a peptide that has shown the ability to stimulate collagen synthesis in a human fibroblast culture and prevent its degradation after the exposure to UVA light. It promotes the production of elastin, hyaluronic acid, glycosaminoglycan, and fibronectin with a visible reduction of wrinkles in terms of length, depth, and roughness. Comparable to retinoic acid with regards to its activity, it does not trigger irritation. Collagen and glycosaminoglycan synthesis are stimulated, the epidermis is reinforced, and wrinkles are diminished.

Palmitoyl Tripeptide-5 is a potent anti-aging ingredient that mimics the effects of thrombospondin-1 (TSP-1), an extracellular matrix protein naturally present in the body. TSP-1 is known for enhancing the activity of transforming growth factor beta (TGFβ), which plays a crucial role in promoting collagen production. The persistent increase in Type I and Type III collagen levels produced by dermal fibroblasts, along with the prevention of collagen degradation, contributes to the peptide's efficacy. By supporting collagen synthesis and inhibiting degradation, Palmitoyl Tripeptide-5 helps reduce the appearance of fine lines and wrinkles, making it a valuable component in skincare formulations designed for rejuvenation and anti-aging benefits.

An unsung hero for a healthy skin barrier. Phytospingosine strengthens the outermost layer of the skin and is very well tolerated and has a wide range of applications. The outermost layer of our skin is responsible for not only keeping moisture from getting out, but also irritants and toxins from getting in. Thus when the barrier is compromised or weakened, unwanted factors can get in, resulting in all kinds of issues from redness to rashes. As well for acne vulgaris different pathogenic factors contribute to the inflammation process. Studies confirmed the strong anti microbial and anti inflammatory activity and the efficassy of phytospingosine adressing acne vulgaris. It strengthens the skin barrier so moisture is kept in and irritants are not let in. It triggers the production of natural moisturizing factors and delivers anti-inflammatory and antibacterial effects.

Phytospingosine is COSMOS registered and is used at levels from 0.1 to 1%